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Can HRT cause Fibroids?

Team Elda
October 19, 2023

Uterine fibroids are noncancerous growths that can develop in the uterus. The hormone Estrogen promotes the growth of uterine fibroids.

Hormone replacement therapy (HRT), now known as MHT, or Menopausal hormonal therapy, typically involves the use of estrogen and progesterone to alleviate symptoms associated with menopause, such as hot flashes, vaginal dryness, mood swings, etc.


It is recommended to use only Estrogen as MHT only in those women in whom the uterus has been removed (hysterectomy) for any (usually non malignant) reason. Otherwise MHT in the form of Estrogen plus Progesterone is recommended so as to counterbalance the effects of unopposed estrogen on the uterus. Such effects could be the unopposed growth of the uterine lining (endometrial hyperplasia) as well as the growth of uterine fibroids. But as MHT in the form of only estrogen is not given in premenopausal women with a uterus, there is no risk of it stimulating the growth  of the fibroids, or increasing the size in case of existing fibroids.

If you are considering or currently using MHT and have concerns about fibroids, it is essential to discuss your specific situation with a healthcare provider who can provide personalised advice and guidance based on your medical history and individual needs. They can evaluate the potential risks and benefits of MHT in relation to fibroids and help you make an informed decision.

Primary Ovarian Insufficiency: Causes and Implications.